In addition to cat's claw herb
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Mechanism of action
Uncaria tomentosa acts as a potent TNF-alpha inhibitor through NF-kappaB.
J Ethnopharmacol. 2010 Feb 17; Allen-Hall L, Arnason JT, Cano P, Lafrenie RM. Laurentian University, Biomolecular Science, Sudbury Regional Hospital, Sudbury, Ontario, Canada.
Uncaria tomentosa, commonly known as Cat's Claw or Uña de gato, is a medicinal plant. We have previously shown that treatment of monocyte-like THP-1 cells with Uncaria tomentosa inhibits the production of the pro-inflammatory cytokine TNF-alpha while augmenting the production of IL-1beta. Since TNF-alpha and IL-1beta are usually regulated similarly and share a number of common promoter elements, including NF-kappaB and AP-1, the ability of Uncaria tomentosa to differentially regulate these inflammatory cytokines is of particular interest. Treatment with Uncaria tomentosa inhibited the LPS-dependent activation of specific NF-kappaB and AP-1 components. In addition, treatment with cat's claw herb enhanced cell death when NF-kappaB was inhibited. The ability of cat's claw herb to inhibit TNF-alpha production was diminished when NF-kappaB activation was prevented by drugs that mask NF-kappaB subunit nuclear localization signals, while IL-1beta expression was unchanged. Our results demonstrate that Uncaria tomentosa is able to elicit a response via an NF-kappaB-dependent mechanism.

Buy cat's claw supplement on sale today. If you buy cat's claw supplement along with Joint Power Rx joint health formula, take each one separately for a few days before combining them.