Calcium D-Glucarate, 500 mg pills
Source of glucaric acid, a beta glucuronidase inhibitor
Source Naturals nutraceutical company
Dietary Supplement. Calcium D-Glucarate is a form of glucaric acid combined with calcium.
D-glucarate is naturally found in some vegetables and fruits, including cruciferous vegetables, bean sprouts and apples. D-glucarat,e in the form of its calcium salt, is marketed as a nutritional supplement.
Source Naturals Calcium D-Glucarate includes the patented compound glucarate which has been shown to enhance the major detoxification pathways in the body. Calcium D-Glucarate is found naturally in the human body and in a variety of fruits and vegetables. Animal studies have shown that Calcium D-Glucarate inhibits Beta-glucuronidase, thereby enhancing the process by which foreign organic compounds, fat-soluble toxins, and excess steroid hormones such as estrogen are detoxified and excreted from our bodies.
Daily intakes above 1,400 mg of calcium are not likely to provide any additional benefits to bone health.
Buy Calcium D-Glucarate Supplement, and Facts:
Serving Size: 2 tablets
Servings per Bottle: 60
Amount Per Serving:
Total Carbohydrates - 1 g
Calcium - 124 mg -10%
(from 1000 mg calcium D-glucarate)
Recommendations: One calcium d-glucarate tablet with a meal one or two times daily, or as recommended by your health care professional.
Other ingredients: Sorbitol, stearic acid, modified cellulose gum, colloidal silicon dioxide, and magnesium stearate.
Suitable for vegetarians. Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.
Caution: For adult use only. Calcium D-glucarate may increase the body's excretion of certain medications. If you are taking medication, or are pregnant or breastfeeding, consult your health care professional before using this product.
The biological role of D-glucaric acid and its derivatives: potential use in medicine.
Postepy Hig Med Dosw (Online). 2008. Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX, USA.
D-glucaric acid is a natural non-toxic compound produced in small amounts by mammals, including humans. In mammals, D-glucaric acid and D-glucaro-l,4-lactone are end-products of the D-glucuronic acid pathway. The enzyme D-glucuronolactone dehydrogenase has been found to be responsible for the oxidation of the lactone of D-glucuronic acid to D-glucaro-l,4;6,3-dilactone. This dilactone hydrolyzes spontaneously in aqueous solution to D-glucaro-l,4-lactone, a potent beta-glucuronidase inhibitor. D-glucaric acid is also found in many fruits and vegetables, with the highest concentrations found in grapefruits, apples, oranges, and cruciferous vegetables. b-glucuronidase is present in the circulation and probably all vertebrate tissues and is capable of hydrolyzing glucuronide conjugates. This enzyme is also produced by colonic microflora. Elevated b-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers such as breast and prostate cancer. D-glucaro-l,4-lactone increases detoxification of carcinogens and tumor promoters by inhibiting b-glucuronidase and preventing the hydrolysis of their glucuronides. D-glucaro-l,4-lactone was found to be formed from supplemented D-glucarate salt in the stomach and it is absorbed from the intestinal track, transported with the blood to different internal organs, and excreted in urine and, to a lesser extent, in bile. D-glucarates not only suppress cell proliferation and inflammation, but also induce apoptosis.
Learn about new calcium d-glucarate research. If you buy calcium d glucarate along with calsium supplements, keep up to date on your total calcium intake.