Bromelain supplement 2400 GDU/Gram, 500 mg
Bromelain is a protease enzyme and a Dietary Supplement.
Bromelain is an enzyme from the pineapple plant which accelerates the breakdown of proteins. It is active in a wide pH range and can function in the acidic environment of the stomach. Bromelain is a combination of several protein-digesting enzymes along with peroxidase, acid phosphatase, protease inhibitors, and calcium. Bromelain is most often used to help digestion and help reduce inflammation. Popular formulas
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Serving Size 1 Capsule
|Amount Per Serving||% Daily Value|
(2400 GDU.* per gram)
*Daily Value not established.
Other ingredients: Gelatin, white rice, magnesium stearate.
Bromelain side effects
Bromelain supplements do not seem to have any obvious side effects with short term use. Bromelain supplements at 800 mg a day were given to a group of patients for a period of 12 weeks without any significant bromelain side effects reported. However, we don't know the benefits or side effects of bromelain supplements when taken uninterrupted for many years.
MCU and GDU units
This enzyme is sometimes listed as MCU units (milk clotting units) or as GDU units (gelatin dissolving units). One GDU is approximately 1.5 MCU.
Protease Supplementation Improves Muscle Function after Eccentric Exercise.
Med Sci Sports Exercise. 2009 Sept 2. Buford TW, Cooke MB, Redd LL, Hudson GM, Shelmadine BD, Willoughby DS. Exercise and Biochemical Nutrition Laboratory, Baylor University, Waco, TX.Protease supplementation has been purported to reduce the damaging effects of eccentric exercise and accelerate recovery of muscle function, possibly by regulating inflammation. To determine the effectiveness of protease supplementation in attenuating eccentric exercise-induced skeletal muscle damage and inflammation. After standard physical and hemodynamic assessment and fasting venous blood samples, subjects performed isokinetic extension/flexion of the quadriceps group on a Biodex isokinetic dynamometer. Subjects were randomly assigned to consume 5.8 g daily of either a cellulose placebo or a proteolytic supplement containing fungal proteases, bromelain, and papain for a period of 21 days. After the supplementation period, subjects donated blood samples before performing a 45-min downhill (-17.5%) treadmill protocol at 60% of V O2max. An additional four blood draws and three muscle function tests were performed during the next 48 h. Significant group differences and another strong trend were observed for flexion indicating higher force production in the protease group. Significant group x time interactions were observed, including elevations in circulating eosinophils and basophils in the protease group coinciding with lower levels of serum cyclooxygenase 2, interleukin 6, and interleukin 12 in this group. Protease supplementation seems to attenuate muscle strength losses after eccentric exercise by regulating leukocyte activity and inflammation.
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